|Application ||WB, E|
|Other Accession||NP_000034.1, NP_690610.1, NP_690611.1, 355|
|Calculated MW||37732 Da|
|Other Names||Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, TNFRSF6|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAS / CD95 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||APT1, FAS1, TNFRSF6|
|Function||Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Secreted.|
|Tissue Location||Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoforms 1 (NP_000034.1), 2 (NP_690610.1) and 3 (NP_690611.1).
Reduced FAS transcription in clones of U937 cells that have acquired resistance to Fas-induced apoptosis. Blomberg J, Ruuth K, Jacobsson M, Höglund A, Nilsson JA, Lundgren E, FEBS J. 2009 Jan 276 (2): 497-508 PMID: 19076218
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