CD80 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P33681 |
Other Accession | NP_005182.1, 941 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 33048 Da |
Gene ID | 941 |
---|---|
Other Names | T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7, CD80, CD80, CD28LG, CD28LG1, LAB7 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CD80 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD80 |
---|---|
Synonyms | CD28LG, CD28LG1, LAB7 |
Function | Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Expressed on activated B-cells, macrophages and dendritic cells |
- Primary Antibodies
- Immunology
- Microbiology
- Signal Transduction
- Antibody Collections
- Goat Antibodies
- Host cell receptor for virus entry
- Viral entry into host cell
- Host-virus interaction
- Toll-Like receptor signaling
- Immune system process
- T cell activation
- Allograft rejection
- Intestinal immune network for IgA production
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Provided below are standard protocols that you may find useful for product applications.
References
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Stephan MT, Ponomarev V, Brentjens RJ, Chang AH, Dobrenkov KV, Heller G, Sadelain M, Nature medicine 2007 Dec 13 (12): 1440-9. PMID: 18026115
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