|Application ||WB, E|
|Other Accession||NP_005182.1, 941|
|Calculated MW||33048 Da|
|Other Names||T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7, CD80, CD80, CD28LG, CD28LG1, LAB7|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD80 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD28LG, CD28LG1, LAB7|
|Function||Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on activated B-cells, macrophages and dendritic cells|
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Provided below are standard protocols that you may find useful for product applications.
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Stephan MT, Ponomarev V, Brentjens RJ, Chang AH, Dobrenkov KV, Heller G, Sadelain M, Nature medicine 2007 Dec 13 (12): 1440-9. PMID: 18026115
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