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WASF1 / WAVE Antibody (internal region)

Peptide-affinity purified goat antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession Q92558
Other Accession NP_003922.1, 8936, 83767 (mouse), 294568 (rat)
Predicted Human, Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 61652 Da
Additional Information
Gene ID 8936
Other Names Wiskott-Aldrich syndrome protein family member 1, WASP family protein member 1, Protein WAVE-1, Verprolin homology domain-containing protein 1, WASF1, KIAA0269, SCAR1, WAVE1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWASF1 / WAVE Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WASF1
Synonyms KIAA0269, SCAR1, WAVE1
Function Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Cellular Location Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250|UniProtKB:Q5BJU7}. Cell junction, focal adhesion. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503)
Tissue Location Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood
Research Areas
Citations (0)

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Background

Reported variants represent identical protein: NP_001020106.1, NP_003922.1, NP_001020107.1, NP_001020105.1

References

WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Beli P, Mascheroni D, Xu D, Innocenti M. Nature cell biology 2008 Jul 10 (7): 849-57. PMID: 18516090

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$ 325.00
Cat# AF3075a
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