|Other Accession||NP_003922.1, 8936, 83767 (mouse), 294568 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||61652 Da|
|Other Names||Wiskott-Aldrich syndrome protein family member 1, WASP family protein member 1, Protein WAVE-1, Verprolin homology domain-containing protein 1, WASF1, KIAA0269, SCAR1, WAVE1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WASF1 / WAVE Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0269, SCAR1, WAVE1|
|Function||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, synapse. Note=Dot-like pattern in the cytoplasm Concentrated in Rac-regulated membrane-ruffling areas|
|Tissue Location||Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001020106.1, NP_003922.1, NP_001020107.1, NP_001020105.1
WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Beli P, Mascheroni D, Xu D, Innocenti M. Nature cell biology 2008 Jul 10 (7): 849-57. PMID: 18516090
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