|Application ||IHC, E|
|Other Accession||NP_055951.2, 23166|
|Predicted||Pig, Dog, Cow|
|Calculated MW||275482 Da|
|Other Names||Stabilin-1, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1, FEEL-1, MS-1 antigen, STAB1, FEEL1, KIAA0246|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Stabilin 1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells|
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Provided below are standard protocols that you may find useful for product applications.
CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. Salmi M, Koskinen K, Henttinen T, Elima K, Jalkanen S, Blood 2004 Dec 104 (13): 3849-57. PMID: 15297319
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