|Other Accession||NP_004527.2, 4671|
|Calculated MW||159582 Da|
|Other Names||Baculoviral IAP repeat-containing protein 1, Neuronal apoptosis inhibitory protein, NAIP, BIRC1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NAIP Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.|
|Tissue Location||Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoform 1 (NP_004527.2).
NAIP and Ipaf control Legionella pneumophila replication in human cells. Vinzing M, Eitel J, Lippmann J, Hocke AC, Zahlten J, Slevogt H, N'guessan PD, Günther S, Schmeck B, Hippenstiel S, Flieger A, Suttorp N, Opitz B. J Immunol. 2008 May 15;180(10):6808-15. PMID: 18453601
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