|Application ||WB, E|
|Other Accession||NP_078894.2, NP_733840.1, 79671|
|Calculated MW||107616 Da|
|Other Names||NLR family member X1, Caterpiller protein 11.3, CLR11.3, Nucleotide-binding oligomerization domain protein 26, Nucleotide-binding oligomerization domain protein 5, Nucleotide-binding oligomerization domain protein 9, NLRX1, NOD26, NOD5, NOD9|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NLRX1 / NOD9 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NOD26, NOD5, NOD9|
|Function||Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).|
|Cellular Location||Mitochondrion outer membrane|
|Tissue Location||Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_078894.2; NP_733840.1).
NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. Tattoli I, Carneiro LA, JÃ©hanno M, Magalhaes JG, Shu Y, Philpott DJ, Arnoult D, Girardin SE, EMBO reports 2008 Mar 9 (3): 293-300. PMID: 18219313
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