|Application ||WB, E|
|Other Accession||NP_003990.1, 9180, 18414 (mouse)|
|Calculated MW||110509 Da|
|Other Names||Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB, OSMR, OSMRB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OSMR Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038).|
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The immunizing peptide represents part of the extracellular domain.
Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK, PLoS genetics 2009 Oct 5 (10): e1000685. PMID: 19834535
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