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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > NPC2 Antibody (internal region)
NPC2 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P61916 |
| Other Accession | NP_006423.1, 10577 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 16570 Da |
| Gene ID | 10577 |
|---|---|
| Other Names | Epididymal secretory protein E1, Human epididymis-specific protein 1, He1, Niemann-Pick disease type C2 protein, NPC2, HE1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NPC2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPC2 (HGNC:14537) |
|---|---|
| Synonyms | HE1 |
| Function | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17018531, PubMed:11125141, PubMed:18772377, PubMed:29580834, PubMed:15937921). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). |
| Cellular Location | Secreted. Endoplasmic reticulum. Lysosome Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes. |
| Tissue Location | Detected in gallbladder bile (PubMed:21315718). Detected in fibroblasts, kidney, liver, spleen, small intestine, placenta and testis (at protein level) (PubMed:11125141). Epididymis |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Regulation of sterol transport between membranes and NPC2. Xu Z, Farver W, Kodukula S, Storch J, Biochemistry 2008 Oct 47 (42): 11134-43. PMID: 18823126
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$ 341.00
Cat# AF3168a
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