|Application ||WB, E|
|Other Accession||NP_006094.3, 10406|
|Calculated MW||12993 Da|
|Other Names||WAP four-disulfide core domain protein 2, Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2, HE4, WAP5|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WFDC2 (aa29-43) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Broad range protease inhibitor.|
|Tissue Location||Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.|
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Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts. Huhtinen K, Suvitie P, Hiissa J, Junnila J, Huvila J, Kujari H, SetÃ¤lÃ¤ M, HÃ¤rkki P, Jalkanen J, Fraser J, MÃ¤kinen J, Auranen A, Poutanen M, Perheentupa A, British journal of cancer 2009 Apr 100 (8): 1315-9. PMID: 19337252
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