|Application ||WB, E|
|Other Accession||NP_000507.1, NP_001070956.1, NP_001070957.1, 2778, 14683 (mouse), 24896 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||67948 Da|
|Other Names||Protein ALEX, Alternative gene product encoded by XL-exon, GNAS (HGNC:4392)|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNAS Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.|
|Cellular Location||Cell membrane; Peripheral membrane protein. Cell projection, ruffle. Note=Predominantly associated with cell membrane ruffles.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all three reported isoforms NP_000507.1, NP_001070956.1 and NP_536350.2. However, in Mouse it is expected to recognize reporterd isoforms GNASL (NP_963910.1) and XLas (NP_034439.2) only.
Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan. Nishihara E, Amino N, Maekawa K, Yoshida H, Ito M, Kubota S, Fukata S, Miyauchi A, Endocrine journal 2009 Dec 56 (6): 791-8. PMID: 19550078
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