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IL12RB1 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P42701 |
| Other Accession | NP_005526.1, 3594 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 73109 Da |
| Gene ID | 3594 |
|---|---|
| Other Names | Interleukin-12 receptor subunit beta-1, IL-12 receptor subunit beta-1, IL-12R subunit beta-1, IL-12R-beta-1, IL-12RB1, IL-12 receptor beta component, CD212, IL12RB1, IL12R, IL12RB |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IL12RB1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL12RB1 |
|---|---|
| Synonyms | IL12R, IL12RB |
| Function | Functions as an interleukin receptor which binds interleukin- 12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform 1 (NP_005526.1) only.
References
Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans. Namkung JH, Lee JE, Kim E, Kim S, Kim S, Shin ES, Cho EY, Yang JM, J Dermatol Sci. 2010 Mar;57(3):199-206. PMID: 20060272
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