PEX26 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q7Z412 |
Other Accession | NP_060399.1, 55670 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 33898 Da |
Gene ID | 55670 |
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Other Names | Peroxisome assembly protein 26, Peroxin-26, PEX26 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PEX26 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PEX26 {ECO:0000303|PubMed:12717447, ECO:0000312|HGNC:HGNC:22965} |
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Function | Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed:12717447, PubMed:12851857, PubMed:16854980, PubMed:21362118, PubMed:16763195, PubMed:16257970). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed:12717447, PubMed:12851857, PubMed:16854980, PubMed:21362118, PubMed:16763195, PubMed:16257970). |
Cellular Location | Peroxisome membrane; Single-pass type II membrane protein |
Tissue Location | Widely expressed (PubMed:12851857). Highly expressed in kidney, liver, brain and skeletal muscles (PubMed:12851857). Expressed at intermediate level in pancreas, placenta and heart (PubMed:12851857). Weakly expressed in lung (PubMed:12851857). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_060399.1, NP_001121121.1
References
Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders. Yik WY, Steinberg SJ, Moser AB, Moser HW, Hacia JG, Human mutation 2009 Mar 30 (3): E467-80. PMID: 19105186
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