|Other Accession||NP_004624.1, NP_001248348.1, 7850|
|Calculated MW||45421 Da|
|Other Names||Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b, Interleukin-1 receptor type 2, membrane form, mIL-1R2, mIL-1RII, Interleukin-1 receptor type 2, soluble form, sIL-1R2, sIL-1RII, IL1R2, IL1RB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL1R2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.|
|Cellular Location||Isoform Short: Secreted|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to cross-react with both reported isoforms (NP_004624.1; NP_001248348.1). Reported variants represent identical protein: NP_775465.1, NP_004624.1
Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma. Sekigawa T, Tajima A, Hasegawa T, Hasegawa Y, Inoue H, Sano Y, Matsune S, Kurono Y, Inoue I, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009 Jul 39 (7): 972-81. PMID: 19489917
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