|Other Accession||NP_001103224.1, NP_002828.3, 5787, 314843 (rat)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||224301 Da|
|Other Names||Receptor-type tyrosine-protein phosphatase beta, Protein-tyrosine phosphatase beta, R-PTP-beta, 188.8.131.52, Vascular endothelial protein tyrosine phosphatase, VE-PTP, PTPRB, PTPB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPRB Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001103224.1; NP_002828.3).
VE-PTP controls blood vessel development by balancing Tie-2 activity. Winderlich M, Keller L, Cagna G, Broermann A, Kamenyeva O, Kiefer F, Deutsch U, Nottebaum AF, Vestweber D, The Journal of cell biology 2009 May 185 (4): 657-71. PMID: 19451274
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