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EIF2B4 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UI10 |
| Other Accession | NP_751945.2, NP_001029288.1, NP_056451.3, 8890, 13667 (mouse), 117019 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Rabbit, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 57557 Da |
| Gene ID | 8890 |
|---|---|
| Other Names | Translation initiation factor eIF-2B subunit delta, eIF-2B GDP-GTP exchange factor subunit delta, EIF2B4, EIF2BD |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EIF2B4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EIF2B4 |
|---|---|
| Synonyms | EIF2BD |
| Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl- initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09924} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_751945.2; NP_001029288.1; NP_056451.3).
References
Identification of novel EIF2B mutations in Chinese patients with vanishing white matter disease. Wu Y, Pan Y, Du L, Wang J, Gu Q, Gao Z, Li J, Leng X, Qin J, Wu X, Jiang Y, Journal of human genetics 2009 Feb 54 (2): 74-7. PMID: 19158808
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