|Other Accession||NP_002964.3, 6311, 20239 (mouse)|
|Predicted||Human, Mouse, Pig, Dog, Cow|
|Calculated MW||140283 Da|
|Other Names||Ataxin-2, Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein, ATXN2, ATX2, SCA2, TNRC13|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATXN2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATX2, SCA2, TNRC13|
|Function||Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.|
|Tissue Location||Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus|
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Multiple common variants for celiac disease influencing immune gene expression. Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwillia Nature genetics 2010 Apr 42 (4): 295-302. PMID: 20190752
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