|Application ||WB, E|
|Other Accession||NP_002658.1, 5350, 64672 (rat)|
|Calculated MW||6109 Da|
|Other Names||Cardiac phospholamban, PLB, PLN, PLB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospholamban / PLN Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.|
|Cellular Location||Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Heart muscle (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy. Møller DV, Pham TT, Gustafsson F, Hedley P, Ersbøll MK, Bundgaard H, Andersen CB, Torp-Pedersen C, Køber L, Christiansen M. European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2009 Nov 11 (11): 1031-5. PMID: 19875404
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