KLHDC8B Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q8IXV7 |
Other Accession | NP_775817.1, 200942, 78267 (mouse), 306589 (rat) |
Reactivity | Human, Mouse |
Predicted | Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 37676 Da |
Gene ID | 200942 |
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Other Names | Kelch domain-containing protein 8B, KLHDC8B |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KLHDC8B Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLHDC8B {ECO:0000303|PubMed:19706467} |
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Function | Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010). |
Cellular Location | Cytoplasm. Midbody. Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis. |
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Provided below are standard protocols that you may find useful for product applications.
References
Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma. Krem MM, Salipante SJ, Horwitz MS, Cell cycle (Georgetown, Tex.) 2010 Feb 9 (4): 670-5. PMID: 20107318
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