|Application ||WB, E|
|Other Accession||NP_005268.1, NP_963885.1, NP_963886.1, 2823, 234267 (mouse), 306439 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||31210 Da|
|Other Names||Neuronal membrane glycoprotein M6-a, M6a, GPM6A, M6A|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPM6A Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine Cell projection, filopodium. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_005268.1; NP_963885.1; NP_963886.1). Reported variants represent identical protein: NP_963885.1, NP_005268.1.
Genomic variation associated with mortality among adults of European and african ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. Morrison AC, Felix JF, Cupples LA, Glazer NL, Loehr LR, Dehghan A, Demissie S, Bis JC, Rosamond WD, Aulchenko YS, Wang YA, Haritunians T, Folsom AR, Rivadeneira F, Benjamin EJ, Lumley T, Couper D, Stricker BH, O'Donnell CJ, Rice KM, Chang PP, Hofman A, Le Circulation. Cardiovascular genetics 2010 Jun 3 (3): 248-55. PMID: 20400778
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