|Application ||WB, E|
|Other Accession||NP_000903.2, 4986, 18387 (mouse), 29335 (rat)|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||42645 Da|
|Other Names||Kappa-type opioid receptor, K-OR-1, KOR-1, OPRK1, OPRK|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OPRK1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in brain and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
N-Glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway. Li JG, Chen C, Liu-Chen LY. Biochemistry. 2007 Sep 25;46(38):10960-70. Epub 2007 Aug 21. PMID: 17711303
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