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BTBD7 Antibody (N-Term)

Peptide-affinity purified goat antibody

     
  • WB - BTBD7 Antibody (N-Term) AF3435a
    MDCK overexpressing Mouse Btbd7 (third lane) and probed with AF3435a (mock transfection in first lane, full construct chemically suppressed in second lane).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9P203
Other Accession NP_001002860.2, NP_060637.1, 55727, 238386 (mouse), 362772 (rat)
Reactivity Mouse
Predicted Human, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 126368 Da
Additional Information
Gene ID 55727
Other Names BTB/POZ domain-containing protein 7, BTBD7, KIAA1525
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBTBD7 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BTBD7
Synonyms KIAA1525
Function Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

This antibody is expected to recognize both reported isoforms (NP_001002860.2; NP_060637.1).

References

Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Onodera T, Sakai T, Hsu JC, Matsumoto K, Chiorini JA, Yamada KM, Science (New York, N.Y.) 2010 Jul 329 (5991): 562-5. PMID: 20671187

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$ 335.00
Cat# AF3435a
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