|Application ||WB, E|
|Other Accession||NP_001002860.2, NP_060637.1, 55727, 238386 (mouse), 362772 (rat)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||126368 Da|
|Other Names||BTB/POZ domain-containing protein 7, BTBD7, KIAA1525|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BTBD7 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001002860.2; NP_060637.1).
Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Onodera T, Sakai T, Hsu JC, Matsumoto K, Chiorini JA, Yamada KM, Science (New York, N.Y.) 2010 Jul 329 (5991): 562-5. PMID: 20671187
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