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SLC47A2 Antibody (internal region, near C-Term)

Peptide-affinity purified goat antibody

     
  • WB - SLC47A2 Antibody (internal region, near C-Term) AF3445a
    AF3445a (0.3 µg/ml) staining of Human Testis lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q86VL8
Other Accession NP_690872.2, NP_001093116.1, 146802
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 65085 Da
Additional Information
Gene ID 146802
Other Names Multidrug and toxin extrusion protein 2, MATE-2, hMATE-2, Kidney-specific H(+)/organic cation antiporter, Solute carrier family 47 member 2, SLC47A2, MATE2
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLC47A2 Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC47A2 (HGNC:26439)
Synonyms MATE2
Function Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney.
Cellular Location Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Detected in the renal urinary tubules.
Tissue Location [Isoform 1]: High expression in kidney. Very small expression in adrenal gland and lung. [Isoform 6]: Ubiquitously expressed in all tissues examined except the kidney.
Research Areas
Citations (0)
citation

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Background

This antibody is expected to recognize both reported isoforms (NP_690872.2; NP_001093116.1).

References

Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds. Ohta KY, Inoue K, Yasujima T, Ishimaru M, Yuasa H, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2009 12 (3): 388-96. PMID: 20067714

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$ 341.00
Cat# AF3445a
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