|Application ||WB, E|
|Other Accession||NP_690872.2, NP_001093116.1, 146802|
|Calculated MW||65085 Da|
|Other Names||Multidrug and toxin extrusion protein 2, MATE-2, hMATE-2, Kidney-specific H(+)/organic cation antiporter, Solute carrier family 47 member 2, SLC47A2, MATE2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC47A2 Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules|
|Tissue Location||Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_690872.2; NP_001093116.1).
Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds. Ohta KY, Inoue K, Yasujima T, Ishimaru M, Yuasa H, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, SociÃ©tÃ© canadienne des sciences pharmaceutiques 2009 12 (3): 388-96. PMID: 20067714
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