|Other Accession||NP_033160.2, 6336, 20264 (mouse), 29571 (rat)|
|Calculated MW||220626 Da|
|Other Names||Sodium channel protein type 10 subunit alpha, Peripheral nerve sodium channel 3, PN3, hPN3, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, SCN10A|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Scn10a / Nav1.8 (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=It can be translocated to the cell membrane through association with S100A10.|
|Tissue Location||Expressed in the dorsal root ganglia and sciatic nerve.|
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Provided below are standard protocols that you may find useful for product applications.
Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. Li Q, Su YY, Wang H, Li L, Wang Q, Bao L, The Journal of biological chemistry 2010 Oct 285 (43): 32977-87. PMID: 20720009
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