|Application ||WB, E|
|Other Accession||NP_006068.2, NP_001182447.1, 10367, 216001 (mouse), 365567 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||54351 Da|
|Other Names||Calcium uptake protein 1, mitochondrial, Atopy-related autoantigen CALC, ara CALC, Calcium-binding atopy-related autoantigen 1, Hom s 4, MICU1, CALC, CBARA1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBARA1 (aa113-126) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space Note=Localizes at the outer surface of the mitochondrion inner membrane|
|Tissue Location||Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoforms 1 and 2 (NP_006068.2; NP_001182447.1).
MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE, Mootha VK, Nature 2010 Sep 467 (7313): 291-6. PMID: 20693986
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