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CBARA1 (aa113-126) Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - CBARA1 (aa113-126) Antibody (internal region) AF3517a
    AF3517a (0.5 µg/ml) staining of K562 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BPX6
Other Accession NP_006068.2, NP_001182447.1, 10367, 216001 (mouse), 365567 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 54351 Da
Additional Information
Gene ID 10367
Other Names Calcium uptake protein 1, mitochondrial, Atopy-related autoantigen CALC, ara CALC, Calcium-binding atopy-related autoantigen 1, Hom s 4, MICU1, CALC, CBARA1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBARA1 (aa113-126) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MICU1
Synonyms CALC, CBARA1
Function Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Cellular Location Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space Note=Localizes at the outer surface of the mitochondrion inner membrane
Tissue Location Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells
Research Areas
Citations (0)

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This antibody is expected to recognize reported isoforms 1 and 2 (NP_006068.2; NP_001182447.1).


MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE, Mootha VK, Nature 2010 Sep 467 (7313): 291-6. PMID: 20693986

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$ 325.00
Cat# AF3517a
(40 western blots)
Availability: 7-10 days
Bulk Size
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