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DBF4B (aa193-207) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q8NFT6 |
| Other Accession | NP_663696.1, NP_079380.1, 80174 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 67243 Da |
| Gene ID | 80174 |
|---|---|
| Other Names | Protein DBF4 homolog B, Activator of S phase kinase-like protein 1, ASK-like protein 1, Chiffon homolog B, Dbf4-related factor 1, DBF4B, ASKL1, DRF1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DBF4B (aa193-207) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DBF4B |
|---|---|
| Synonyms | ASKL1, DRF1 |
| Function | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. |
| Cellular Location | Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction |
| Tissue Location | Widely expressed. Highly expressed in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms.
References
The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. Tsuji T, Lau E, Chiang GG, Jiang W. Mol Cell. 2008 Dec 26;32(6):862-9. PMID: 19111665
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