|Other Accession||NP_663696.1, NP_079380.1, 80174|
|Calculated MW||67243 Da|
|Other Names||Protein DBF4 homolog B, Activator of S phase kinase-like protein 1, ASK-like protein 1, Chiffon homolog B, Dbf4-related factor 1, DBF4B, ASKL1, DRF1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DBF4B (aa193-207) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.|
|Cellular Location||Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction|
|Tissue Location||Widely expressed. Highly expressed in testis.|
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This antibody is expected to recognize both reported isoforms.
The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. Tsuji T, Lau E, Chiang GG, Jiang W. Mol Cell. 2008 Dec 26;32(6):862-9. PMID: 19111665
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