|Other Accession||NP_663696.1, NP_079380.1, 80174|
|Calculated MW||67243 Da|
|Other Names||Protein DBF4 homolog B, Activator of S phase kinase-like protein 1, ASK-like protein 1, Chiffon homolog B, Dbf4-related factor 1, DBF4B, ASKL1, DRF1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DBF4B (aa193-207) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.|
|Cellular Location||Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction|
|Tissue Location||Widely expressed. Highly expressed in testis.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms.
The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. Tsuji T, Lau E, Chiang GG, Jiang W. Mol Cell. 2008 Dec 26;32(6):862-9. PMID: 19111665
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.