|Application ||WB, E|
|Other Accession||NP_542400.2, 113235|
|Calculated MW||49771 Da|
|Other Names||Proton-coupled folate transporter, G21, Heme carrier protein 1, PCFT/HCP1, Solute carrier family 46 member 1, SLC46A1, HCP1, PCFT|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC46A1 / PCFT (aa233-247) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.|
|Cellular Location||Apical cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells.|
|Tissue Location||Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon.|
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Provided below are standard protocols that you may find useful for product applications.
Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT SLC46A1); a D156Y mutation causing hereditary folate malabsorption. Shin DS, Min SH, Russell L, Zhao R, Fiser A, Goldman ID. Blood. 2010 Dec 9;116(24):5162-9. PMID: 20805364
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