|Application ||WB, E|
|Other Accession||NP_071878.2, NP_001171275.1, 23410, 64384 (mouse), 293615 (rat)|
|Predicted||Human, Rat, Pig|
|Calculated MW||43573 Da|
|Other Names||NAD-dependent protein deacetylase sirtuin-3, mitochondrial, hSIRT3, 3.5.1.-, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, SIRT3, SIR2L3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Sirtuin 3 (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_071878.2; NP_001171275.1). Reported variants represent identical proteins: NP_071878.2; NP_001120823.1
Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y. PLoS One. 2010 Jul 22;5(7):e11707. PMID: 20661474
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