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PKD1 (aa2281-2292) Antibody (C-Term)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P98161
Other Accession NP_001009944.2, NP_000287.3, 5310, 18763 (mouse), 24650 (rat)
Predicted Human, Mouse, Rat, Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 462529 Da
Additional Information
Gene ID 5310
Other Names Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPKD1 (aa2281-2292) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PKD1
Function Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear- mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein- carbohydrate interactions.
Cellular Location Membrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250|UniProtKB:O08852}. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain (By similarity) Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). {ECO:0000250|UniProtKB:O08852}
Research Areas
Citations (0)

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This antibody is expected to recognize both reported isoforms (NP_001009944.2; NP_000287.3).


Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. AbouAlaiwi WA, Ratnam S, Booth RL, Shah JV, Nauli SM. Hum Mol Genet. 2011 Jan 15;20(2):354-67. PMID: 21041232

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$ 325.00
Cat# AF3578a
(40 western blots)
Availability: 7-10 days
Bulk Size
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