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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > PKD1 (aa2281-2292) Antibody (C-Term)
PKD1 (aa2281-2292) Antibody (C-Term)
Peptide-affinity purified goat antibody
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Application 
| E |
|---|---|
| Primary Accession | P98161 |
| Other Accession | NP_001009944.2, NP_000287.3, 5310, 18763 (mouse), 24650 (rat) |
| Predicted | Human, Mouse, Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 462529 Da |
| Gene ID | 5310 |
|---|---|
| Other Names | Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PKD1 (aa2281-2292) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PKD1 (HGNC:9008) |
|---|---|
| Function | Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid- flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow- induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria (PubMed:37681898). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250|UniProtKB:O08852}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O08852}. Golgi apparatus {ECO:0000250|UniProtKB:O08852}. Vesicle Secreted, extracellular exosome Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain. PKD1:PKD2 interaction is required to reach the Golgi apparatus from endoplasmic reticulum and then traffic to the cilia (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). Cell surface localization requires GANAB (PubMed:27259053). Detected on migrasomes and on extracellular exosomes in urine (PubMed:37681898) {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:27259053, ECO:0000269|PubMed:37681898} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_001009944.2; NP_000287.3).
References
Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. AbouAlaiwi WA, Ratnam S, Booth RL, Shah JV, Nauli SM. Hum Mol Genet. 2011 Jan 15;20(2):354-67. PMID: 21041232
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$ 341.00
Cat# AF3578a
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