|Application ||WB, E|
|Other Accession||NP_835471.1, NP_001186976.1, 349565|
|Calculated MW||28322 Da|
|Other Names||Nicotinamide mononucleotide adenylyltransferase 3, NMN adenylyltransferase 3, Nicotinate-nucleotide adenylyltransferase 3, NaMN adenylyltransferase 3, 18.104.22.168, Pyridine nucleotide adenylyltransferase 3, PNAT-3, 22.214.171.124, NMNAT3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NMNAT3 (aa149-162) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.|
|Tissue Location||Expressed in lung and spleen with lower levels in placenta and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_835471.1; NP_001186976.1).
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate
analogues, and isozyme contributions to NAD+ biosynthesis. Sorci L, Cimadamore F, Scotti S, Petrelli R, Cappellacci L, Franchetti P,
Orsomando G, Magni G. Biochemistry. 2007 Apr 24;46(16):4912-22. PMID: 17402747
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