|Application ||WB, E|
|Other Accession||NP_002498.1, 4804, 18053 (mouse), 24596 (rat)|
|Predicted||Human, Pig, Cow|
|Calculated MW||45183 Da|
|Other Names||Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||p75NTR / CD271 (aa202-215) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize the extracellular domain of p75NTR.
Human neurotrophin receptor p75NTR defines differentiation-oriented skeletal muscle precursor cells: implications for muscle regeneration. Colombo E, Romaggi S, Medico E, Menon R, Mora M, Falcone C, Lochmüller H, Confalonieri P, Mantegazza R, Morandi L, Farina C. J Neuropathol Exp Neurol. 2011 Feb;70(2):133-42. PMID: 21343882
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