OCT6 (aa192-204) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q03052 |
Other Accession | NP_002690.3, 5453, 18991 (mouse), 192110 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Pig, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 45496 Da |
Gene ID | 5453 |
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Other Names | POU domain, class 3, transcription factor 1, Octamer-binding protein 6, Oct-6, Octamer-binding transcription factor 6, OTF-6, POU domain transcription factor SCIP, POU3F1, OCT6, OTF6 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | OCT6 (aa192-204) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | POU3F1 |
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Synonyms | OCT6, OTF6 |
Function | Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P21952}. |
Tissue Location | Expressed in embryonal stem cells and in the developing brain |
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Provided below are standard protocols that you may find useful for product applications.
References
Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. Ryu EJ, Wang JY, Le N, Baloh RH, Gustin JA, Schmidt RE, Milbrandt J. J Neurosci. 2007 Oct 24;27(43):11552-9. PMID: 17959798
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