SLC22A16 (aa97-110) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
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Primary Accession | Q86VW1 |
Other Accession | NP_149116.2, 85413 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 64614 Da |
Gene ID | 85413 |
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Other Names | Solute carrier family 22 member 16, Carnitine transporter 2, CT2, Fly-like putative transporter 2, FLIPT2, Flipt 2, Organic cation transporter OKB1, Organic cation/carnitine transporter 6, SLC22A16, OCT6 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC22A16 (aa97-110) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC22A16 (HGNC:20302) |
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Synonyms | OCT6 |
Function | Facilitative organic cation transporter that mediates the transport of carnitine as well as the polyamine spermidine (PubMed:12089149, PubMed:20037140). Mediates the partially Na(+)- dependent bidirectional transport of carnitine (PubMed:12089149). May mediate L-carnitine secretion from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa (PubMed:12089149). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis |
Tissue Location | Expressed in testis and epididymis (at protein level) (PubMed:12384147, PubMed:12089149, PubMed:15963465). Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase (PubMed:17197897). Expressed at lower levels in adult tissues including bone marrow (at protein level) (PubMed:12372408, PubMed:12384147, PubMed:15963465). Expressed in hematopoietic cells, including CD34(+) leukocytes (PubMed:12384147) Expressed in fetal liver (at protein level), brain, lung, kidney, heart, skeletal muscle, spleen and thymus (PubMed:12372408, PubMed:12384147, PubMed:15963465). Expressed in leukemia cells (PubMed:12384147). Abundantly expressed in ovarian cancer clear-cell adenocarcinoma (PubMed:17581421). |
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Provided below are standard protocols that you may find useful for product applications.
References
The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. Aouida M, Poulin R, Ramotar D. J Biol Chem. 2010 Feb 26;285(9):6275-84. PMID: 20037140
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