|Application ||WB, E|
|Other Accession||NP_853547.1, 8131, 17168 (mouse), 360505 (rat)|
|Calculated MW||63605 Da|
|Other Names||Nitrogen permease regulator 3-like protein, -14 gene protein, Alpha-globin regulatory element-containing gene protein, Protein CGTHBA, NPRL3, C16orf35, CGTHBA, MARE|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Nprl3 (mouse) Antibody (internal region, N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.|
|Cellular Location||Lysosome membrane. Note=Localization to lysosomes is amino acid-independent.|
|Tissue Location||Widely expressed. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888)|
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Provided below are standard protocols that you may find useful for product applications.
Conservation of position and
sequence of a novel, widely expressed gene containing the major human
alpha-globin regulatory element. Vyas P, Vickers MA, Picketts DJ, Higgs DR. Genomics. 1995 Oct 10;29(3):679-89. PMID: 8575760
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