|Application ||WB, E|
|Other Accession||NP_003245.1, 7076, 116510 (rat)|
|Calculated MW||23171 Da|
|Other Names||Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIMP1 (aa129-143) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.|
|Tissue Location||Detected in rheumatoid synovial fluid (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Generation of antibodies recognizing an aberrant glycoform of human tissue inhibitor of metalloproteinase-1 (TIMP-1) using decoy immunization and phage display. Ahn HJ, Kim YS, Lee CH, Cho EW, Yoo HS, Kim SH, Ko JH, Kim SJ. Biotechnol. 2011 Jan 20;151(2):225-30. PMID: 21167221
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