|Application ||WB, E|
|Other Accession||NP_001659.1, 405, 11863 (mouse), 25242 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||86636 Da|
|Other Names||Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT, BHLHE2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARNT (aa69-82) Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoform 1 (NP_001659.1) only.
ETV6-ARNT fusion in a patient with childhood T lymphoblastic
leukemia. Otsubo K, Kanegane H, Eguchi M, Eguchi-Ishimae M, Tamura K, Nomura K, Abe A, Ishii E, Miyawaki T. Cancer Genet Cytogenet. 2010 Oct 1;202(1):22-6. PMID: 20804916
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