|Other Accession||NP_000071.1, 1145|
|Calculated MW||54697 Da|
|Other Names||Acetylcholine receptor subunit epsilon, CHRNE, ACHRE|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRNE (aa185-197) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The immunizing peptide represents a part of an extracellular domain
AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands. Faber CG, Molenaar PC, Vles JS, Bonifati DM, Verschuuren JJ, van Doorn PA, Kuks JB, Wokke JH, Beeson D, De Baets M. J Neurol. 2009 Oct;256(10):1719-23. PMID: 19544078
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