|Application ||WB, E|
|Other Accession||NP_005402.3, NP_001087239.2, NP_001158117.1, NP_001158118.1, NP_001092138.1, 653509, 729238|
|Calculated MW||26242 Da|
|Other Names||Pulmonary surfactant-associated protein A1, PSP-A, PSPA, SP-A, SP-A1, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-4, SFTPA1, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFTPA1 / SFTPA2 (aa102-115) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B|
|Function||In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all the reported isoforms of A1 (NP_005402.3; NP_001087239.2; NP_001158117.1; NP_001158118.1) and A2 ( NP_001092138.1), Reported variants represent identical protein: NP_001158116.1, NP_005402.3, NP_001158119.1
Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Benlhabib H, Mendelson CR. Mol Cell Biol. 2011 May;31(10):1949-58. PMID: 21402781
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