|Application ||WB, E|
|Other Accession||NP_004156.1, 6236, 56437 (mouse), 83521 (rat)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||33245 Da|
|Other Names||GTP-binding protein RAD, RAD1, Ras associated with diabetes, RRAD, RAD|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RRAD (aa36-48) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.|
|Cellular Location||Cell membrane.|
|Tissue Location||Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_004156.1, NP_001122322.1
A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment. Lee I, Yeom SY, Lee SJ, Kang WK, Park C. Cancer Res. 2010 Jun 1;70(11):4357-65. PMID: 20460530
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.