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RRAD (aa36-48) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P55042 |
| Other Accession | NP_004156.1, 6236, 56437 (mouse), 83521 (rat) |
| Reactivity | Mouse |
| Predicted | Human, Rat, Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 33245 Da |
| Gene ID | 6236 |
|---|---|
| Other Names | GTP-binding protein RAD, RAD1, Ras associated with diabetes, RRAD, RAD |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RRAD (aa36-48) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RRAD |
|---|---|
| Synonyms | RAD |
| Function | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L- type Ca(2+) currents (By similarity). Regulates voltage-dependent L- type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin- dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (PubMed:18056528). |
| Cellular Location | Cell membrane. |
| Tissue Location | Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_004156.1, NP_001122322.1
References
A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment. Lee I, Yeom SY, Lee SJ, Kang WK, Park C. Cancer Res. 2010 Jun 1;70(11):4357-65. PMID: 20460530
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