|Application ||WB, E|
|Other Accession||NP_001526.2, NP_001229793.1, NP_001229794.1, NP_001229795.1, 3275, 15468 (mouse), 499420 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||49042 Da|
|Other Names||Protein arginine N-methyltransferase 2, 2.1.1.-, Histone-arginine N-methyltransferase PRMT2, 188.8.131.52, PRMT2, HMT1, HRMT1L1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRMT2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation.|
|Cellular Location||Isoform 1: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus Isoform PRMT2Beta: Cytoplasm. Nucleus. Nucleus, nucleolus Isoform PRMT2L2: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic|
|Tissue Location||Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1). Reported variants represent identical protein: NP_001526.2, NP_996845.1
A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity. Pak ML, Lakowski TM, Thomas D, Vhuiyan MI, Hüsecken K, Frankel A. Biochemistry. 2011 Sep 27;50(38):8226-40. PMID: 21851090
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