|Application ||WB, E|
|Other Accession||NP_001526.2, NP_001229793.1, NP_001229794.1, NP_001229795.1, 3275, 15468 (mouse), 499420 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||49042 Da|
|Other Names||Protein arginine N-methyltransferase 2, 2.1.1.-, Histone-arginine N-methyltransferase PRMT2, 18.104.22.168, PRMT2, HMT1, HRMT1L1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRMT2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation.|
|Cellular Location||Isoform 1: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus Isoform PRMT2Beta: Cytoplasm. Nucleus. Nucleus, nucleolus Isoform PRMT2L2: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic|
|Tissue Location||Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1). Reported variants represent identical protein: NP_001526.2, NP_996845.1
A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity. Pak ML, Lakowski TM, Thomas D, Vhuiyan MI, Hüsecken K, Frankel A. Biochemistry. 2011 Sep 27;50(38):8226-40. PMID: 21851090
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.