|Other Accession||NP_001338.2, 1609|
|Calculated MW||101155 Da|
|Other Names||Diacylglycerol kinase theta, DAG kinase theta, 22.214.171.124, Diglyceride kinase theta, DGK-theta, DGKQ, DAGK4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DGKQ (aa295-298) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.|
|Cellular Location||Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to the nucleus in response to thrombin stimulation (PubMed:15632189). Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189)|
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Provided below are standard protocols that you may find useful for product applications.
Negative regulation of diacylglycerol kinase theta mediates adenosine dependent hepatocyte preconditioning. Baldanzi G, Alchera E, Imarisio C, Gaggianesi M, Dal Ponte C, Nitti M, Domenicotti C, van Blitterswijk WJ, Albano E, Graziani A, Carini R. Cell Death Differ. 2010 Jun;17(6):1059-68. PMID: 20057501
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