|Application ||WB, IHC, E|
|Other Accession||NP_573469.1, NP_001162093.1, 84937, 170737 (mouse), 690769 (rat)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||23783 Da|
|Other Names||E3 ubiquitin-protein ligase ZNRF1, 6.3.2.-, Nerve injury-induced gene 283 protein, Zinc/RING finger protein 1, ZNRF1, NIN283|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNRF1 (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).|
|Cellular Location||Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Associated with synaptic vesicle membranes in neurons|
|Tissue Location||Expressed primarily in the nervous system, with expression higher in developing brain relative to adult Expressed at low levels in testis and thymus|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoforms a and b (NP_573469.1; NP_001162093.1). Reported variants represent identical protein: NP_001162092.1, NP_573469.1
: . PMID:
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