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Ubinuclein 1 / ubinuclein 2 Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - Ubinuclein 1 / ubinuclein 2 Antibody (internal region) AF3797a
    AF3797a (1 µg/ml) staining of MOLT4 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NPG3
Other Accession NP_058632.2, 29855, 170644 (mouse), 302935 (rat)
Reactivity Human
Predicted Mouse, Rat, Zebrafish, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 121520 Da
Additional Information
Gene ID 29855
Other Names Ubinuclein-1, HIRA-binding protein, Protein VT4, Ubiquitously expressed nuclear protein, UBN1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUbinuclein 1 / ubinuclein 2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBN1
Function Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly.
Cellular Location Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis
Tissue Location Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
Research Areas
Citations (0)

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Reported variants represent identical protein: NP_058632.2, NP_001072982.1.


The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells. Gruffat H, Lupo J, Morand P, Boyer V, Manet E. J Virol. 2011 Jan;85(2):784-94. PMID: 21084479

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$ 325.00
Cat# AF3797a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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