|Application ||WB, E|
|Other Accession||NP_058632.2, 29855, 170644 (mouse), 302935 (rat)|
|Predicted||Mouse, Rat, Zebrafish, Pig, Dog, Cow|
|Calculated MW||121520 Da|
|Other Names||Ubinuclein-1, HIRA-binding protein, Protein VT4, Ubiquitously expressed nuclear protein, UBN1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Ubinuclein 1 / ubinuclein 2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis|
|Tissue Location||Ubiquitous. Also expressed in numerous tumors and cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_058632.2, NP_001072982.1.
The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells. Gruffat H, Lupo J, Morand P, Boyer V, Manet E. J Virol. 2011 Jan;85(2):784-94. PMID: 21084479
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