|Other Accession||NP_058640.1, 50832|
|Calculated MW||33841 Da|
|Other Names||Taste receptor type 2 member 4, T2R4, TAS2R4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAS2R4 (aa157-171) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed on airway ciliated epithelium|
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Provided below are standard protocols that you may find useful for product applications.
The immunizing peptide represents part of an extracellular domain.
Evolution of bitter taste receptors in humans and apes. Fischer A, Gilad Y, Man O, Pääbo S. Mol Biol Evol. 2005 Mar;22(3):432-6. PMID: 15496549
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