|Application ||WB, E|
|Other Accession||NP_000730.1, 1129, 243764 (mouse)|
|Predicted||Human, Pig, Dog, Cow|
|Calculated MW||51715 Da|
|Other Names||Muscarinic acetylcholine receptor M2, CHRM2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRM2 (aa352-364) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001006628.1, NP_001006633.1, NP_001006627.1, NP_000730.1, NP_001006629.1, NP_001006630.1, NP_001006631.1, NP_001006632.1.
Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. Hendershot CS, Bryan AD, Ewing SW, Claus ED, Hutchison KE. J Abnorm Child Psychol. 2011 Jul;39(5):671-81. PMID: 21494862
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