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Uromodulin (aa525-536) Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - Uromodulin (aa525-536) Antibody (internal region) AF3814a
    AF3814a (0.5 µg/ml) staining of HeLa lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07911
Other Accession NP_003352.2, 7369
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 69761 Da
Additional Information
Gene ID 7369
Other Names Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, Uromodulin, secreted form, UMOD
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUromodulin (aa525-536) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial.
Cellular Location Apical cell membrane; Lipid- anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI- anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalized with NPHP1 and KIF3A
Tissue Location Expressed in the tubular cells of the kidney (at protein level). Synthesized exclusively in the kidney Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen Most abundant protein in normal urine
Research Areas
Citations (0)

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Reported variants represent identical protein: NP_001008390.1, NP_003352.2


Uromodulin gene variant is associated with type 2 diabetic nephropathy. Ahluwalia TS, Lindholm E, Groop L, Melander O. J Hypertens. 2011 Sep;29(9):1731-4. PMID: 21738052

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$ 325.00
Cat# AF3814a
(40 western blots)
Availability: 7-10 days
Bulk Size
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