|Application ||WB, E|
|Other Accession||NP_003352.2, 7369|
|Calculated MW||69761 Da|
|Other Names||Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, Uromodulin, secreted form, UMOD|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Uromodulin (aa525-536) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).|
|Cellular Location||Apical cell membrane; Lipid- anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization (PubMed:22776760). Secreted into urine after cleavage (PubMed:18375198, PubMed:26811476). Colocalizes with NPHP1 and KIF3A (PubMed:20172860).|
|Tissue Location||Expressed in the tubular cells of the kidney. Most abundant protein in normal urine (at protein level) Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001008390.1, NP_003352.2
Uromodulin gene variant is associated with type 2 diabetic nephropathy. Ahluwalia TS, Lindholm E, Groop L, Melander O. J Hypertens. 2011 Sep;29(9):1731-4. PMID: 21738052
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