|Application ||WB, E|
|Other Accession||NP_005243.1, 2353|
|Predicted||Pig, Dog, Cow, Cat|
|Calculated MW||40695 Da|
|Other Names||Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, FOS, G0S7|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||c-FOS (aa283-295) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.|
|Cellular Location||Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30|
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Provided below are standard protocols that you may find useful for product applications.
c-Fos regulates hepatitis C virus propagation. Kang SM, Lim S, Won SJ, Shin YJ, Lim YS, Ahn BY, Hwang SB. FEBS Lett. 2011 Oct 20;585(20):3236-44. PMID: 21920361
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