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TSPAN14 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NG11 |
| Other Accession | NP_112189.2, NP_001121781.1, 81619, 52588 (mouse), 306324 (rat) |
| Reactivity | Mouse |
| Predicted | Human, Rat, Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 30691 Da |
| Gene ID | 81619 |
|---|---|
| Other Names | Tetraspanin-14, Tspan-14, DC-TM4F2, Transmembrane 4 superfamily member 14, TSPAN14, TM4SF14 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSPAN14 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSPAN14 (HGNC:23303) |
|---|---|
| Synonyms | TM4SF14 |
| Function | Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:23035126, PubMed:26668317, PubMed:37516108). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_112189.2; NP_001121781.1).
References
Identification of genes associated with non-small-cell lung cancer promotion and progression. Bankovic J, Stojsic J, Jovanovic D, Andjelkovic T, Milinkovic V, Ruzdijic S, Tanic N. Lung Cancer. 2010 Feb;67(2):151-9. PMID: 19473719
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