|Application ||WB, E|
|Other Accession||NP_060740.1, 55257, 73247 (mouse), 311713 (rat)|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||22417 Da|
|Other Names||MRG/MORF4L-binding protein, MRG-binding protein, Up-regulated in colon cancer 4, Urcc4, MRGBP, C20orf20|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MRG/MORF4L binding protein Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.|
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Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma. Watt S.A. et al. Oncogene. 2011 Nov 17;30(46):4666-77. PMID: 21602893
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