myotilin (aa209-221) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9UBF9 |
Other Accession | NP_006781.1, NP_001129412.1, 9499 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 55395 Da |
Gene ID | 9499 |
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Other Names | Myotilin, 57 kDa cytoskeletal protein, Myofibrillar titin-like Ig domains protein, Titin immunoglobulin domain protein, MYOT, TTID |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | myotilin (aa209-221) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MYOT |
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Synonyms | TTID |
Function | Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. |
Cellular Location | Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Sarcomeric, also localized to the sarcolemma (PubMed:10369880). Colocalizes with MYOZ1 at the Z-lines in skeletal muscle (PubMed:16076904). |
Tissue Location | Expressed in skeletal muscle (at protein level). Expressed in skeletal muscle, heart, bone marrow and thyroid gland |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_006781.1; NP_001129412.1).
References
Analysis of myotilin turnover provides mechanistic insight into the role of myotilinopathy-causing mutations. von Nandelstadh P, Soliymani R, Baumann M, Carpen O. Biochem J. 2011 May 15;436(1):113-21. PMID: 21361873
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