|Application ||WB, E|
|Other Accession||NP_006781.1, NP_001129412.1, 9499|
|Calculated MW||55395 Da|
|Other Names||Myotilin, 57 kDa cytoskeletal protein, Myofibrillar titin-like Ig domains protein, Titin immunoglobulin domain protein, MYOT, TTID|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||myotilin (aa209-221) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells.|
|Cellular Location||Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Sarcomeric, also localized to the sarcolemma (PubMed:10369880). Colocalizes with MYOZ1 at the Z-lines in skeletal muscle (PubMed:16076904)|
|Tissue Location||Expressed in skeletal muscle (at protein level). Expressed in skeletal muscle, heart, bone marrow and thyroid gland.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_006781.1; NP_001129412.1).
Analysis of myotilin turnover provides mechanistic insight into the role of myotilinopathy-causing mutations. von Nandelstadh P, Soliymani R, Baumann M, Carpen O. Biochem J. 2011 May 15;436(1):113-21. PMID: 21361873
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